3/9/2023 0 Comments Thessa confluence rarP = 0.0353 (according to two-sided Fisher’s exact test). The analysis of NAT2 revealed no significant differences between controls and any patient subgroup. Patients were sub-grouped according to cytogenetics (normal, non-complex, complex) and in t-AML/MDS according to primary malignancy (Hodgkin’s lymphoma (HL), non-Hodgkin’s lymphoma (NHL) and breast cancer). NAT2-polymorphisms (fast metabolisers, heterozygotes and slow metabolisers) were analysed in 352 patients (196 AML, 156 MDS, 28 t-AML/MDS) and compared with 240 controls. The polymorphisms of GSTT1 and GSTM1 were examined in 439 patients (265 AML, 174 MDS, 65 t-AML/MDS) and compared with 248 healthy controls. Data were compared with the results of 266 healthy controls. GSTP1-poymorphisms were analysed in blood samples or bone marrow of 326 patients (180 AML, 146 MDS) of whom 65 had therapy-related malignancies (t-AML/t-MDS) by PCR/RFLP analysis. To extend our database by a higher number of individuals examined and by determining the occurrence of NAT2and two GSTP1-polymorphisms (Exon 5: Ile105Val and Exon 6: Ala114Val). Recently, our group could demonstrate a significantly increased risk for t-AML/MDS after breast cancer-therapy in individuals with a double deletion of GSTT1 and GSTM1. Thus, further efforts are needed to clarify the relevance of polymorphisms of metabolising enzymes for the pathogenesis of de novo and secondary malignancies. Recent studies examined the role of these enzymes in carcino- and leukemogenesis. Trümper Department of Hematologgy/Oncology, University of Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany ∗ E-mail: Glutathione S-transferases (GST) and N-acetyltransferases metabolise exogenous and endogenous compounds. Leukemia Research 27 Supplement Numer 1 (2003) S1–S123ħth International Symposium on Myelodysplastic Syndromes-Abstracts EPIDEMIOLOGY POLYMORPHISMS OF METABOLIZING ENZYMES (NAT2, GSTT1, GSTM1 AND GSTP1) IN DE NOVO AND THERAPY-INDUCED MDS AND AML D.
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